The deadliest roads in Missouri
I-70 had the most fatal crashes of any numbered road in Missouri from 2015 to 2024: 342, with 369 deaths. The 60 roads listed held 50% of all fatal crashes in Missouri from 2015 to 2024; 9 are interstates, 13 US routes, 38 state highways.
251 numbered roads in Missouri recorded a fatal crash in those years; the 60 with 5 or more are ranked below, and 34 have a page of their own. All fatal crashes in Missouri.
Every numbered road in Missouri, ranked by fatal crashes
| Road | Kind | Fatal crashes | Deaths | 2022 to 2024 | Counties with the most | |
|---|---|---|---|---|---|---|
| 1 | I-70 | Interstate | 342 | 369 | 107 | Jackson, St. Charles, St. Louis city |
| 2 | I-44 | Interstate | 268 | 305 | 89 | Franklin, Phelps, St. Louis |
| 3 | I-55 | Interstate | 175 | 190 | 49 | Jefferson, St. Louis, St. Louis city |
| 4 | US 61 | US route | 156 | 172 | 54 | Jefferson, Lincoln, St. Charles |
| 5 | US 60 | US route | 155 | 177 | 54 | Webster, Greene, Lawrence |
| 6 | US 63 | US route | 149 | 174 | 41 | Boone, Howell, Texas |
| 7 | US 67 | US route | 134 | 142 | 31 | St. Louis, St. Francois, Jefferson |
| 8 | US 54 | US route | 117 | 151 | 34 | Camden, Callaway, Cole |
| 9 | US 65 | US route | 116 | 126 | 30 | Greene, Taney, Pettis |
| 10 | US 50 | US route | 111 | 119 | 38 | Johnson, Jackson, Franklin |
| 11 | I-435 | Interstate | 100 | 108 | 30 | Jackson, Clay, Platte |
| 12 | State Highway 13 | State highway | 99 | 111 | 32 | Polk, Johnson, Stone |
| 13 | I-270 | Interstate | 89 | 97 | 31 | St. Louis, St. Louis city |
| 14 | I-49 | Interstate | 86 | 95 | 31 | Cass, Jackson, Newton |
| 15 | State Highway D | State highway | 84 | 98 | 15 | St. Louis, Cass, St. Charles |
| 16 | State Highway 5 | State highway | 83 | 98 | 26 | Laclede, Camden, Morgan |
| 17 | State Highway H | State highway | 83 | 92 | 29 | St. Louis city, Jefferson, Clay |
| 18 | State Highway B | State highway | 76 | 82 | 23 | Boone, Jefferson, Cape Girardeau |
| 19 | State Highway 30 | State highway | 75 | 85 | 22 | Jefferson, St. Louis city, St. Louis |
| 20 | US 160 | US route | 74 | 81 | 20 | Taney, Christian, Ripley |
| 21 | State Highway 21 | State highway | 70 | 74 | 23 | Jefferson, Washington, Reynolds |
| 22 | US 71 | US route | 65 | 73 | 19 | Jackson, McDonald, Andrew |
| 23 | State Highway 7 | State highway | 60 | 66 | 22 | Henry, Cass, Benton |
| 24 | US 24 | US route | 58 | 64 | 22 | Jackson, Lafayette, Randolph |
| 25 | State Highway N | State highway | 58 | 61 | 23 | St. Charles, Cape Girardeau, Platte |
| 26 | I-29 | Interstate | 57 | 67 | 12 | Platte, Holt, Atchison |
| 27 | State Highway 32 | State highway | 57 | 61 | 19 | Laclede, St. Francois, Dent |
| 28 | State Highway C | State highway | 56 | 60 | 12 | Dent, Lincoln, Cole |
| 29 | State Highway 19 | State highway | 55 | 63 | 11 | Shannon, Montgomery, Crawford |
| 30 | State Highway 47 | State highway | 53 | 61 | 13 | Franklin, Lincoln, Washington |
| 31 | State Highway M | State highway | 53 | 57 | 17 | Ray, Webster, Butler |
| 32 | State Highway E | State highway | 51 | 52 | 10 | Lincoln, Wayne, Iron |
| 33 | US 36 | US route | 50 | 61 | 18 | Linn, Marion, DeKalb |
| 34 | State Highway 76 | State highway | 50 | 51 | 18 | Taney, Barry, Stone |
| 35 | State Highway A | State highway | 48 | 53 | 15 | Jefferson, Webster, Camden |
| 36 | State Highway O | State highway | 47 | 52 | 17 | Ste. Genevieve, Pettis, Butler |
| 37 | I-35 | Interstate | 47 | 50 | 10 | Clay, Clinton, Jackson |
| 38 | State Highway F | State highway | 46 | 49 | 11 | Taney, Jackson, Ralls |
| 39 | State Highway 100 | State highway | 45 | 48 | 15 | Franklin, St. Louis, St. Louis city |
| 40 | State Highway K | State highway | 45 | 46 | 14 | Reynolds, Franklin, St. Charles |
| 41 | State Highway J | State highway | 44 | 47 | 13 | Dunklin, Lincoln, Stoddard |
| 42 | State Highway 94 | State highway | 44 | 44 | 10 | St. Charles, Warren, Callaway |
| 43 | State Highway W | State highway | 43 | 47 | 13 | Morgan, Butler, Warren |
| 44 | US 40 | US route | 43 | 45 | 9 | Jackson, Howard, Boone |
| 45 | State Highway U | State highway | 42 | 49 | 13 | St. Louis, New Madrid, Newton |
| 46 | State Highway Y | State highway | 42 | 44 | 9 | St. Francois, Morgan, Miller |
| 47 | US 169 | US route | 41 | 45 | 13 | Clay, Buchanan, Andrew |
| 48 | I-64 | Interstate | 38 | 43 | 9 | St. Louis, St. Charles, St. Louis city |
| 49 | State Highway T | State highway | 36 | 37 | 13 | St. Charles, Gasconade, Butler |
| 50 | State Highway 43 | State highway | 35 | 38 | 18 | Jasper, Newton, McDonald |
| 51 | State Highway 291 | State highway | 33 | 37 | 13 | Jackson, Cass, Clay |
| 52 | State Highway Z | State highway | 33 | 37 | 9 | Boone, Greene, Lafayette |
| 53 | State Highway 72 | State highway | 32 | 36 | 11 | Bollinger, Phelps, Madison |
| 54 | State Highway V | State highway | 31 | 36 | 5 | Jefferson, Lawrence, Jackson |
| 55 | State Highway 141 | State highway | 31 | 31 | 11 | St. Louis, Jefferson |
| 56 | State Highway 86 | State highway | 30 | 34 | 11 | Newton, Barry, Taney |
| 57 | State Highway 367 | State highway | 30 | 33 | 6 | St. Louis |
| 58 | State Highway 51 | State highway | 30 | 32 | 9 | Perry, Butler, Stoddard |
| 59 | State Highway 25 | State highway | 29 | 32 | 6 | Stoddard, Dunklin, Cape Girardeau |
| 60 | State Highway CC | State highway | 29 | 31 | 7 | Greene, Webster, Jefferson |
Source: NHTSA Fatality Analysis Reporting System (FARS), 2024 Annual Report File (released April 2026, subject to revision). How we count
Download every numbered road in Missouri as CSV. Free to reuse with credit: “Fatal Crash Data, fatalcrashdata.com/deadliest-roads/missouri/, from NHTSA FARS (2024 Annual Report File).”
Interstates in Missouri per mile
Fatal crashes a year per 100 miles of road, 2015 to 2024, for interstates with 20 miles or more in Missouri. Crashes per mile of road, not per vehicle. Mileage from the FHWA Interstate route log.
Source: NHTSA Fatality Analysis Reporting System (FARS), 2024 Annual Report File (released April 2026, subject to revision). How we count
Questions about the deadliest roads in Missouri
- What is the deadliest road in Missouri?
- I-70 had the most fatal crashes of any numbered road in Missouri from 2015 to 2024: 342, with 369 deaths. I-44 was second with 268 and I-55 third with 175. Source: NHTSA's Fatality Analysis Reporting System (FARS).
- Which interstate in Missouri is the most dangerous per mile?
- I-70, with 13.7 fatal crashes a year per 100 miles over 2015 to 2024 on 249 miles. That is crashes per mile of road, not per vehicle.
- How many fatal crashes in Missouri happen on numbered roads?
- 5,914 of 8,801 fatal crashes in Missouri from 2015 to 2024 (67%) were filed on an interstate, US or state route; the rest were on county roads, city streets and unnamed roads, which are in the state's total but not ranked here.
Where the Missouri road numbers come from
Counted from NHTSA's Fatality Analysis Reporting System, 2024 Annual Report File: every fatal crash filed on a numbered interstate, US or state route in Missouri, read from the road name NHTSA filed, with ramps, frontage and service roads left out. A road gets its own page with 15 or more fatal crashes from 2022 to 2024. The full method.