What is the deadliest road in South Carolina?

US 17 had the most fatal crashes of any numbered road in South Carolina from 2015 to 2024: 418, with 452 deaths. I-26 was second with 288 and I-95 third with 225. Source: NHTSA's Fatality Analysis Reporting System (FARS).

Which interstate in South Carolina is the most dangerous per mile?

I-77, with 14.7 fatal crashes a year per 100 miles over 2015 to 2024 on 91 miles. That is crashes per mile of road, not per vehicle.

How many fatal crashes in South Carolina happen on numbered roads?

8,988 of 9,692 fatal crashes in South Carolina from 2015 to 2024 (93%) were filed on an interstate, US or state route; the rest were on county roads, city streets and unnamed roads, which are in the state's total but not ranked here.

The deadliest roads in South Carolina

US 17 had the most fatal crashes of any numbered road in South Carolina from 2015 to 2024: 418, with 452 deaths. The 60 roads listed held 54% of all fatal crashes in South Carolina from 2015 to 2024; 6 are interstates, 22 US routes, 32 state highways.

806 numbered roads in South Carolina recorded a fatal crash in those years; the 60 with 5 or more are ranked below, and 44 have a page of their own. All fatal crashes in South Carolina.

Every numbered road in South Carolina, ranked by fatal crashes

	Road	Kind	Fatal crashes	Deaths	2022 to 2024	Counties with the most
1	US 17	US route	418	452	112	Horry, Charleston, Berkeley
2	I-26	Interstate	288	332	70	Spartanburg, Lexington, Orangeburg
3	I-95	Interstate	225	266	53	Colleton, Clarendon, Jasper
4	US 76	US route	206	213	63	Richland, Anderson, Sumter
5	US 52	US route	179	191	67	Charleston, Berkeley, Florence
6	US 25	US route	167	178	44	Greenville, Greenwood, Aiken
7	I-20	Interstate	159	173	41	Richland, Lexington, Aiken
8	US 21	US route	156	176	48	Beaufort, York, Orangeburg
9	State Highway 9	State highway	149	162	50	Horry, Spartanburg, Lancaster
10	I-85	Interstate	140	160	39	Spartanburg, Anderson, Greenville
11	US 1	US route	135	147	36	Richland, Aiken, Lexington
12	I-77	Interstate	134	152	42	Richland, York, Chester
13	US 29	US route	134	144	44	Greenville, Spartanburg, Anderson
14	US 176	US route	133	139	43	Spartanburg, Berkeley, Richland
15	State Highway 34	State highway	98	105	23	Fairfield, Kershaw, Newberry
16	US 15	US route	97	108	31	Sumter, Darlington, Marlboro
17	US 501	US route	94	98	28	Horry, Marion, Dillon
18	US 378	US route	90	105	29	Lexington, Sumter, Florence
19	US 278	US route	86	92	20	Beaufort, Aiken, Jasper
20	US 321	US route	86	91	26	Orangeburg, Lexington, Jasper
21	US 301	US route	85	94	32	Orangeburg, Dillon, Clarendon
22	State Highway 6	State highway	83	87	25	Lexington, Orangeburg, Berkeley
23	US 221	US route	76	89	18	Spartanburg, Greenwood, Laurens
24	US 178	US route	76	85	23	Orangeburg, Lexington, Pickens
25	State Highway 20	State highway	74	76	19	Greenville, Charleston, Anderson
26	US 521	US route	73	81	27	Lancaster, Sumter, Kershaw
27	State Highway 41	State highway	68	74	22	Marion, Williamsburg, Berkeley
28	State Highway 61	State highway	68	72	15	Charleston, Dorchester, Colleton
29	State Highway 72	State highway	67	76	17	Chester, York, Laurens
30	US 78	US route	66	74	21	Charleston, Dorchester, Aiken
31	State Highway 28	State highway	65	70	21	Anderson, McCormick, Oconee
32	State Highway 11	State highway	62	68	18	Oconee, Spartanburg, Greenville
33	State Highway 19	State highway	55	61	23	Aiken, Horry, Darlington
34	State Highway 49	State highway	55	59	13	York, Union, Laurens
35	State Highway 31	State highway	54	60	19	Horry, Spartanburg, Richland
36	State Highway 642	State highway	53	61	21	Charleston, Dorchester
37	State Highway 14	State highway	53	60	16	Greenville, Laurens, Darlington
38	US 276	US route	53	54	15	Greenville
39	State Highway 24	State highway	50	60	9	Anderson, Florence, Oconee
40	State Highway 22	State highway	50	54	12	Horry, Anderson, Chesterfield
41	US 601	US route	49	51	21	Richland, Chesterfield, Orangeburg
42	State Highway 81	State highway	48	52	17	Anderson, Greenville, Aiken
43	US 701	US route	46	47	16	Horry, Georgetown
44	I-385	Interstate	45	53	17	Greenville, Laurens
45	State Highway 5	State highway	45	50	5	York, Lancaster, Cherokee
46	US 123	US route	45	46	16	Pickens, Greenville, Oconee
47	State Highway 29	State highway	44	46	11	Berkeley, Horry, Florence
48	State Highway 13	State highway	43	45	9	Charleston, Florence, Darlington
49	State Highway 183	State highway	42	46	14	Greenville, Pickens, Oconee
50	State Highway 101	State highway	41	45	11	Spartanburg, Laurens, Greenville
51	State Highway 21	State highway	40	43	9	Greenville, Colleton, Darlington
52	State Highway 291	State highway	40	43	15	Greenville, Pickens
53	State Highway 38	State highway	40	43	7	Marlboro, Dillon, Georgetown
54	State Highway 48	State highway	38	41	11	Richland, Kershaw, Berkeley
55	State Highway 62	State highway	38	39	17	Berkeley, Dorchester, Spartanburg
56	State Highway 57	State highway	37	39	12	Florence, Horry, Dillon
57	State Highway 51	State highway	36	42	13	Florence, Georgetown, Lancaster
58	State Highway 64	State highway	35	38	13	Colleton, York, Clarendon
59	State Highway 46	State highway	34	38	12	Beaufort, Jasper, Laurens
60	State Highway 39	State highway	34	37	9	Aiken, Saluda, Laurens

Source: NHTSA Fatality Analysis Reporting System (FARS), 2024 Annual Report File (released April 2026, subject to revision). How we count

Download every numbered road in South Carolina as CSV. Free to reuse with credit: “Fatal Crash Data, fatalcrashdata.com/deadliest-roads/south-carolina/, from NHTSA FARS (2024 Annual Report File).”

Interstates in South Carolina per mile

Fatal crashes a year per 100 miles of road, 2015 to 2024, for interstates with 20 miles or more in South Carolina. Crashes per mile of road, not per vehicle. Mileage from the FHWA Interstate route log.

	Road	Per 100 miles a year	Fatal crashes	Miles
1	I-77	14.7	134	91
2	I-85	13.2	140	106
3	I-26	13.0	288	221
4	I-95	11.3	225	199
5	I-20	11.2	159	142

Source: NHTSA Fatality Analysis Reporting System (FARS), 2024 Annual Report File (released April 2026, subject to revision). How we count

Questions about the deadliest roads in South Carolina

What is the deadliest road in South Carolina?: US 17 had the most fatal crashes of any numbered road in South Carolina from 2015 to 2024: 418, with 452 deaths. I-26 was second with 288 and I-95 third with 225. Source: NHTSA's Fatality Analysis Reporting System (FARS).
Which interstate in South Carolina is the most dangerous per mile?: I-77, with 14.7 fatal crashes a year per 100 miles over 2015 to 2024 on 91 miles. That is crashes per mile of road, not per vehicle.
How many fatal crashes in South Carolina happen on numbered roads?: 8,988 of 9,692 fatal crashes in South Carolina from 2015 to 2024 (93%) were filed on an interstate, US or state route; the rest were on county roads, city streets and unnamed roads, which are in the state's total but not ranked here.

Where the South Carolina road numbers come from

Counted from NHTSA's Fatality Analysis Reporting System, 2024 Annual Report File: every fatal crash filed on a numbered interstate, US or state route in South Carolina, read from the road name NHTSA filed, with ramps, frontage and service roads left out. A road gets its own page with 15 or more fatal crashes from 2022 to 2024. The full method.